's fault that I drew this
I have seen "Blood: The Last Vampire" several times, as I own the movie, but hadn't really paid attention to the various manga that came out after the movie was release, or the anime adaptation, "Blood+".
The thing that hit me about the difference in character design for Saya is that she's a lot more innocent looking in "Blood+" than in "BtLV". I've only seen the first few episodes of the anime, but it looks pretty good.
Drawn in PS with Wacom tablet; textures from [link]